Half Life Of Prozac

It has an active metabolite norfluoxetine which has a very long half life 4 14 days so it can take about five weeks to fully get rid of it. Half life of fluoxetine prozac the half life of a medication is the approximate time it takes to reduce to half strength in your plasma.

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Fluoxetine itself has a half life of 2 4 days but as it is processed your body creates an active antidepressant metabolite norfluoxetine which has a half life of 7 15 days.

Half life of prozac. Because of this yes dose adjustments m. Because of this yes dose adjustments m. Yes prozac fluoxetine has a longer half life of approximately 5 7 days eliminated usually in several weeks.

The half life of fluoxetine is about four to six days. So prozac keeps on extending its half life as it is metabolized. Similarly the half life of norfluoxetine is longer 16 days after long term use.

Accumulation and slow elimination the relatively slow elimination of fluoxetine elimination half life of 1 to 3 days after acute administration and 4 to 6 days after chronic administration and its active metabolite norfluoxetine elimination half life of 4 to 16 days after acute and chronic administration leads to significant accumulation of these active species in chronic use and delayed attainment of steady state even when a fixed dose is used see warnings and precautions 5 14. After you take it for a few days half life is about 16 days. This may be an advantage as the chance of getting the ssri withdrawal syndrome is far less.

With time fluoxetine and norfluoxetine inhibit their own metabolism so fluoxetine elimination half life changes from 1 to 3 days after a single dose to 4 to 6 days after long term use. It has the longest half life of any ssri. Any good information is appreciated.

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