Fenofibrate Mechanism Of Action
Fenofibrate is a fibric acid derivative a prodrug comprising fenofibric acid linked to an isopropyl ester. 8 11 12 pparα is a nuclear receptor and its activation alters lipid glucose and amino acid homeostasis.
Mechanism of action of fenofibrate fenofibrate belongs to a class of drugs that exert their effects by activating the peroxisome proliferator activated receptor α pparα a transcription factor that regulates lipid metabolism via a number of routes.
Fenofibrate mechanism of action. Induction of lipoprotein lipolysis. Fenofibrate is a peroxisome proliferator receptor alpha agonist. Mechanism of action protocol.
Fenofibrate mechanism of action fenofibrate are comes from the fibrate groups. It lowers lipid levels by activating peroxisome proliferator activated receptor alpha pparα. 8 activation of pparα activates transcription of gene transcription and translation that generates peroxisomes filled with hydrogen peroxide reactive oxygen species and hydroxyl radicals that also.
Chemical name of fenofibrate is 2 4 4 chlorobenzoyl phenoxy 2 methyl propanoic acid. This medicine are helps to activate the enzyme lipoprotein lipase. Through this mechanism fenofibrate increases lipolysis and elimination of triglyceride rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein c iii an inhibitor of lipoprotein lipase activity.
Through this mechanism fenofibrate increases lipolysis and elimination of triglyceride rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein c iii an inhibitor of lipoprotein lipase activity. The mechanism of action of fenofibrate is as a peroxisome proliferator activated receptor alpha agonist. Fenofibrate also inhibits human cytochrome p450 isoforms with ic50s of 0 2 0 7 9 7 4 8 and 142 1 μm for cyp2c19 cyp2b6 cyp2c9 cyp2c8 and cyp3a4 respectively.
Fenofibrate is a selective pparα agonist with an ec50 of 30 μm. The chemical classification of fenofibrate is ppar alpha. Fenofibrate activates peroxisome proliferator activated receptor alpha pparα increasing lipolysis activating lipoprotein lipase and reducing apoprotein c iii.
Mechanisms of action of fibrates evidence from studies in rodents and in humans is available to implicate 5 major mechanisms underlying the above mentioned modulation of lipoprotein phenotypes by fibrates.
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