Dapsone Mechanism Of Action

Other proposed mechanisms for dapsone include inhibition of the neutrophilic cytotoxic system and interference with the alternate pathway of the complement system. Dapsone when given orally is rapidly and almost completely absorbed.

Dapsone Metabolic Pathway Ugt Glucuronosyltransferase Sult1ai

The mechanism of action in dermatitis herpetiformis has not been established.

Dapsone mechanism of action. Mechanism of action of dapsone dapsone is an antileprotic sulfone chemically related to sulfonamides has same mechanism of action. Dapsone is rapidly and well absorbed following oral administration and is primarily. Pharmacokinetics in a pharmacokinetic study male and female subjects 16 years of age or older with acne vulgaris n 19 received 2 grams of dapsone gel 7 5 topically to the face upper chest upper back and shoulders once daily for 28 days.

With three different mechanisms of action dapsone has established a broad area of coverage in both systemic and skin diseases. Dapsone is a sulfone derived medication that was first used in humans to treat leprosy in the 1940s. Dapsone is a chemical class different from sulfonamides but its mechanism of action is similar to sulfonamides via inhibition of bacterial synthesis of dihydrofolic acid by competing with para aminobenzoate for the active site of dihydropteroate synthase.

Mechanism of action similar to sulfonamides dapsone inhibits dihyropteroate synthase in susceptible organisms. Dapsone is a synthetic derivative of diamino sulfone with anti inflammatory and anti bacterial properties. It exerts it s bacteriostatic action by acting as an antimetabolite by inhibiting bacterial folic acid synthesis.

Dapsone acts against bacteria and protozoa in the same way as sulphonamides that is by inhibiting the synthesis of dihydrofolic acid through competition with para amino benzoate for the active site of dihydropteroate synthetase. Though structurally distinct from dapsone the sulfonamide group of antibacterial drugs also work in this way. Para amino benzoic acid paba is a constituent of bacterial folic acid.

1 since then it has been used as an antimicrobial agent and has been found to have anti inflammatory properties. The anti inflammatory action of the drug is unrelated to its antibacterial action and is still. As an antibiotic dapsone is commonly used to treat mycobacterium leprae the causative organism of leprosy.

By the kinetic method in mice dapsone is bactericidal as well as bacteriostatic against mycobacterium leprae. As an antibacterial dapsone inhibits bacterial synthesis of dihydrofolic acid via competition with para aminobenzoate for the active site of dihydropteroate synthase thereby inhibiting nucleic acid synthesis. The mechanism of action of dapsone gel in treating acne vulgaris is not known.

It is used in a number of dermatologic conditions particularly those with neutrophil predominance as it inhibits neutrophil activation and recruitment through a. As a structural analog of p aminobenzoic acid dapsone inhibits dihydropteroate synthase dhps an enzyme important in folate synthesis resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for dna synthesis. Also it is used to prophylax against pneumocystis pneumonia and toxoplasmosis in hiv patients as well.

Dapsone Colchicine