Etoposide Mechanism Of Action In Cancer
Etoposide is a semisynthetic derivative of the podophyllotoxins an epipodophyllotoxin. Etoposide phosphate is a prodrug formulation of etoposide.
Etoposide is cell cycle dependent and phase specific affecting mainly the s and g2 phases of.
Etoposide mechanism of action in cancer. However there is incomplete information about its exact mechanism of action in induction of cell death. Etoposide was compared at various concentrations to characterize the mechanisms by which it induces cell death. It is used in patients who have already been treated with surgery radiation therapy or other chemotherapy and have not gotten better.
We investigated its effects on mouse embryonic fibroblasts mefs. Etoposide mechanism of action etoposide is a prescription medicine used in combination with other chemotherapy drugs to treat certain types of cancer. Depending on the particular form of the medication being used this drug can help treat small cell lung cancer or testicular cancer in adults.
This formulation has greater solubility allowing for more rapid infusion with less hypersensitivity and hypotensive reactions. Etoposide is used to treat small cell lung cancer. Etoposide may also be used for purposes not listed in this medication guide.
It is used with other chemotherapy as first line treatment. Etoposide is cell cycle dependent and phase specific affecting mainly the s and g 2 phases. Teniposide has a similar mechanism of action to etoposide but with higher potency.
Side effects are very common. Etoposide sold under the brand name etopophos among others is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer lung cancer lymphoma leukemia neuroblastoma and ovarian cancer. Etoposide inhibits dna topoisomerase ii thereby inhibiting dna re ligation.
Etoposide has been used clinically in cancer treatment as well as in numerous research studies for many years. It inhibits dna topoisomerase ii thereby inhibiting dna synthesis. It is used by mouth or injection into a vein.
It is usually given in combination with other cancer medicines. It is also used for hemophagocytic lymphohistiocytosis. Current uses include treatment of refractory childhood.
Metabolism studies of the antitumor drug etoposide show the formation of metabolites in the lactone ring which are probably not important for the drug s mechanism of action and oxidative transformations in the dimethoxyphenol ring e ring which lead to products that can cause dna damage and may play a role in the drug s mechanism of action. 8 8 mechanism of action. Small cell lung cancer.
This causes critical errors in dna synthesis at the premitotic stage of cell division and can lead to apoptosis of the cancer cell. Etoposide is approved to be used with other drugs to treat. Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
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